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Amvasc Capsules 30’S

INDICATIONS: Hypertension Chronic stable angina pectoris. Vasospastic (Prinzmetal's) angina CONTRAINDICATIONS: Amlodipine is contraindicated in patients with: - Hypersensitivity to dihydropyridine derivatives, amlodipine or any of the excipients - Severe hypotension. - Shock (including cardiogenic shock) - Obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis) - haemodynamically unstable heart failure after acute myocardial infarction ADVERSE REACTIONS: Headache, edema, dizziness, fatigue, flushing and nausea palpitations, rash, pruritus, impotence, muscle cramps, weakness, dyspepsia. POSOLOGY AND ADMINISTRATION: Adults For both hypertension and angina the usual initial dose is 5 mg Amlodipine once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response. Paediatric The recommended antihypertensive oral dose in paediatric patients ages 6-17 years is 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in paediatric patients Special populations Use in elderly Amlodipine, used at similar doses in elderly or younger patients , is equally well tolerated. Use in renal failure Amlodipine, may be used in renal failure patients at normal doses. Amlodipine is not dialysable. Use in patients with impaired hepatic function As with other calcium channel blockers; amlodipine half life is prolonged in patients with impaired hepatic function. The drug should therefore be administered with caution in these patients. Use in pregnancy & nursing mothers Amlodipine should be used during pregnancy only if the potential benefit outweighs the potential risk to the mother and fetus. Amlodipine should not be given to nursing mothers

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INDICATIONS: Hypertension Chronic stable angina pectoris. Vasospastic (Prinzmetal’s) angina

CONTRAINDICATIONS: Amlodipine is contraindicated in patients with: – Hypersensitivity to dihydropyridine derivatives, amlodipine or any of the excipients – Severe hypotension. – Shock (including cardiogenic shock) – Obstruction of the outflow tract of the left ventricle (e.g. high grade aortic stenosis) – haemodynamically unstable heart failure after acute myocardial infarction.

ADVERSE REACTIONS: Headache, edema, dizziness, fatigue, flushing and nausea palpitations, rash, pruritus, impotence, muscle cramps, weakness, dyspepsia.

POSOLOGY AND ADMINISTRATION: Adults For both hypertension and angina the usual initial dose is 5 mg Amlodipine once daily which may be increased to a maximum dose of 10 mg depending on the individual patient’s response. Paediatric The recommended antihypertensive oral dose in paediatric patients ages 6-17 years is 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in paediatric patients Special populations Use in elderly Amlodipine, used at similar doses in elderly or younger patients , is equally well tolerated. Use in renal failure Amlodipine, may be used in renal failure patients at normal doses. Amlodipine is not dialysable. Use in patients with impaired hepatic function As with other calcium channel blockers; amlodipine half life is prolonged in patients with impaired hepatic function. The drug should therefore be administered with caution in these patients. Use in pregnancy & nursing mothers Amlodipine should be used during pregnancy only if the potential benefit outweighs the potential risk to the mother and fetus. Amlodipine should not be given to nursing mothers

WEIGHT

10MG, 2.5MG, 5MG

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